Amino-PEG4-t-butyl ester
ALDRICH/902535
Synonym: tert-Butyl 1-
CAS Number: 581065-95-4
Empirical Formula (Hill Notation): C15H31NO6
Molecular Weight: 321.41
MDL Number: MFCD11041116
Linear Formula: C15H31NO6
Product Type: Chemical
| density | 1.04479 g/mL |
| form | liquid |
| functional group | amine |
| ester | |
| InChI | 1S/C15H31NO6/c1-15(2,3)22 |
| InChI key | PKESARRNSGIDRD-UHFFFAOYSA |
| reaction suitability | reagent type: cross-linking reagent |
| refractive index | n |
| SMILES string | NCCOCCOCCOCCOCCC(OC(C)(C) |
| storage temp. | −20°C |
| Application: | This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation  .Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Real-time monitoring of vesicle pH in an endocytic pathway using an EGF-conjugated two-photon probe  Development of Substrate-Selective Probes for Affinity Pulldown of Histone Demethylases A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.04479 g/mL |
| Refractive Index | n |
| Storage Temp. | −20°C |
| UNSPSC | 51171641 |