Propargyl-PEG4-acid
ALDRICH/902543
Synonym: 4,7,10,13-
CAS Number: 1415800-32-6
Empirical Formula (Hill Notation): C12H20O6
Molecular Weight: 260.28
MDL Number: MFCD22683284
Linear Formula: C12H20O6
Product Type: Chemical
| availability | available only in USA |
| density | 1.164 g/mL |
| form | liquid |
| functional group | alkyne |
| carboxylic acid | |
| reaction suitability | reagent type: linker |
| refractive index | n |
| SMILES string | OC(CCOCCOCCOCCOCC#C)=O |
| storage temp. | −20°C |
| Application: | This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation  .Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Design, Synthesis, and Evaluation of Novel 1,2,3-Triazole-Tethered Glycolipids as Vaccine Adjuvants  |
| Symbol |  GHS02 |
| Signal word | Danger |
| Hazard statements | H242 |
| Precautionary statements | P210 - P234 - P235 - P240 - P370 + P378 - P403 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.164 g/mL |
| Refractive Index | n |
| Storage Temp. | −20°C |
| UNSPSC | 12352106 |