BocNH-PEG4-acid
ALDRICH/902551
Synonym: 2,2-
CAS Number: 876345-13-0
Empirical Formula (Hill Notation): C15H29NO8
Molecular Weight: 351.39
Linear Formula: C15H29NO8
Product Type: Chemical
| density | 1.1395 g/mL |
| form | liquid |
| functional group | amine |
| Boc | |
| carboxylic acid | |
| reaction suitability | reaction type: Pegylations |
| reagent type: cross-linking reagent | |
| refractive index | n |
| SMILES string | OC(COCCOCCOCCOCCNC(OC(C)( |
| storage temp. | −20°C |
| Application: | This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation  Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications  A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Density | 1.1395 g/mL |
| Refractive Index | n |
| Storage Temp. | −20°C |
| UNSPSC | 12352106 |