Hydroxy-PEG6-t-butyl ester
ALDRICH/902578 - ≥95%
Synonym: tert-Butyl 1-
CAS Number: 361189-64-2
Empirical Formula (Hill Notation): C19H38O9
Molecular Weight: 410.50
Linear Formula: C19H38O9
Product Type: Chemical
| assay | ≥95% |
| density | 1.068 |
| form | liquid |
| functional group | ester |
| hydroxyl | |
| InChI | 1S/C19H38O9/c1-19(2,3)28- |
| InChI key | VGGDPFAYSOSIOK-UHFFFAOYSA |
| reaction suitability | reagent type: cross-linking reagent |
| refractive index | n |
| SMILES string | O=C(OC(C)(C)C)CCOCCOCCOCC |
| storage temp. | −20°C |
| Application: | This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation  . |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR  Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Density | 1.068 |
| Refractive Index | n |
| Storage Temp. | −20°C |
| UNSPSC | 51171641 |