(S,R,S)-AHPC-PEG₃-azide

ALDRICH/904651 - ≥95%

Synonym: (2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; Crosslinker−E3 Ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader; VH032 conjugate

CAS Number: 1797406-80-4
Empirical Formula (Hill Notation): C₃₀H₄₃N₇O₇S
Molecular Weight: 645.77
Linear Formula: C₃₀H₄₃N₇O₇S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-904651-50MG	50 mg	$566.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	solid or liquid
functional group	azide
ligand	VH032
reaction suitability	reaction type: click chemistry
	reagent type: ligand-linker conjugate
SMILES string	O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN=[N+]=[N-])=O)=O
storage temp.	2-8°C

Application:	Protein degrader building block (S,R,S)-AHPC-PEG₃-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	2-8°C
UNSPSC	51171641

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