Pomalidomide-PEG3-azide

ALDRICH/904678

Synonym: 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide; Crosslinker−E3 Ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader

CAS Number: 2267306-15-8
Empirical Formula (Hill Notation): C₂₁H₂₄N₆O₈
Molecular Weight: 488.45
Linear Formula: C₂₁H₂₄N₆O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-904678-50MG	50 mg	$663.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 904678-50MG.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder
functional group	azide
ligand	pomalidomide
mp	165 °C
reaction suitability	reaction type: click chemistry
	reagent type: ligand-linker conjugate
SMILES string	O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCOCCOCCN=[N+]=[N-])=O)=O)NC1=O
storage temp.	2-8°C

Application:	Protein degrader builiding block Pomalidomide-PEG3-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
mp	165 °C
Storage Temp.	2-8°C
UNSPSC	51171641

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