Pomalidomide-PEG2-butyl iodide
ALDRICH/904724 - ≥95%
Synonym: Crosslinker–E3 Ligase ligand conjugate; Pomalidomide-2-2-6-I, N-
CAS Number: 1835705-72-0
Empirical Formula (Hill Notation): C23H28IN3O7
Molecular Weight: 585.39
Linear Formula: C23H28IN3O7
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 904724-50MG.
| assay | ≥95% |
| form | powder or crystals |
| functional group | alkyl halide |
| ligand | pomalidomide |
| reaction suitability | reactivity: sulfuryl reactive |
| reagent type: ligand-linker conjugate | |
| SMILES string | ICCCCCCOCCOCC(NC1=CC=CC2= |
| storage temp. | 2-8°C |
| Application: | Protein degrader builiding block Pomalidomide-PEG2-butyl Iodide enables the synthesis of molecules for targeted protein degradation  and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeting the C481S Ibrutinib-Resistance Mutation in Bruton′s Tyrosine Kinase Using PROTAC-Mediated Degradation  Modular PROTAC Design for the Degradation of Oncogenic BCR-?ABL Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352101 |