Pomalidomide-C6-PEG1-C3-PEG1-butyl azide
ALDRICH/904880 - ≥95%
Synonym: Crosslinker−E3 ligase ligand conjugate; Pomalidomide-6-5-6-N3, 6-
Empirical Formula (Hill Notation): C30H42N6O7
Molecular Weight: 598.69
Linear Formula: C30H42N6O7
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 904880-50MG.
| assay | ≥95% |
| form | powder or crystals |
| functional group | azide |
| ligand | pomalidomide |
| reaction suitability | reaction type: click chemistry |
| reagent type: ligand-linker conjugate | |
| SMILES string | O=C(C(CC1)N(C2=O)C(C3=C2C |
| storage temp. | 2-8°C |
| Application: | Protein degrader builiding block Pomalidomide-C6-PEG1-C3-PEG1-butyl azide enables the synthesis of molecules for targeted protein degradation  and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules  Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | 2-8°C |
| UNSPSC | 51171641 |