(S,R,S)-AHPC-PEG₂-butyl chloride

ALDRICH/905399

Synonym: (2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; (S,R,S)-AHPC-2-2-6-Cl; Crosslinker−E3 ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader; VH032 conjugate

CAS Number: 1835705-57-1
Empirical Formula (Hill Notation): C₃₂H₄₇ClN₄O₆S
Molecular Weight: 651.26
MDL Number: MFCD31560480
Linear Formula: C₃₂H₄₇ClN₄O₆S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-905399-50MG	50 mg	$583.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	liquid
functional group	alkyl halide
ligand	VH032
reaction suitability	reactivity: sulfuryl reactive
	reagent type: ligand-linker conjugate
SMILES string	ClCCCCCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
storage temp.	2-8°C

Application:	Protein degrader builiding block (S,R,S)-AHPC-PEG₂-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	2-8°C
UNSPSC	12352101

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