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H-L-Photo-lysine HCl

ALDRICH/907251 - ≥98%

Synonym: (S)-2-Amino-6-((2-(3-methyl-3H-diazirin-3-yl)ethoxy)carbonylamino)hexanoic acid hydrochloride; (S)-2-Amino-6-((2-(3H-diazirin-3-yl)propoxy)carbonylamino)hexanoic acid hydrochloride; 3′-Azibutyl-N-carbamoyl-lysine hydrochloride; Abk; Diazirine amino acid; Photo-Lys; Photo-crosslinking amino acid; Photoprobe building block

CAS Number: 1253643-88-7 (free base)
Empirical Formula (Hill Notation): C11H21ClN4O4
Molecular Weight: 308.76
Linear Formula: C11H21ClN4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-907251-100MG 100 mg
 $541.00
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application(s) peptide synthesis
assay ≥98%
availability available only in USA
form powder
InChI 1S/C11H20N4O4/c1-11(14-15-11)5-7-19-10(18)13-6-3-2-4-8(12)9(16)17/h8H,2-7,12H2,1H3,(H,13,18)(H,16,17)/t8-/m0/s1
InChI key LUCMNTLJAFTFDU-QMMMGPOBSA-N
reaction suitability reaction type: solution phase peptide synthesis
storage temp. −20°C
Application: H-L-Photo-lysine HCl is a diazirine-containing lysine  amino acid and multifunctional probe building blocks . Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (~360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907383.

Product can be used with our line of photoreactors : Including Penn PhD (Z744035 ) & SynLED 2.0 (Z744080 )
Other Notes: A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation 

Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking</A

Genetic code expansion for multiprotein complex engineering 

Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells 

Probing Protein-Protein Interactions with a Genetically Encoded Photo-crosslinking Amino Acid 

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis 

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs) 
Purity ≥98%
Storage Temp. −20°C
UNSPSC 12352209

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