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H-L-Photo-Proline hydrochloride

ALDRICH/907286 - ≥95%

Synonym: (S)-1,2,5-Triazaspiro[2.4]hept-1-ene-6-carboxylic acid; Diazirine amino acid; Photo-Pro; Photo-crosslinking amino acid; Photoprobe building block

Empirical Formula (Hill Notation): C5H8ClN3O2
Molecular Weight: 177.59
Linear Formula: C5H8ClN3O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-907286-100MG 100 mg
$534.00
1/EA
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application(s) peptide synthesis
assay ≥95%
form powder
reaction suitability reaction type: solution phase peptide synthesis
storage temp. −20°C
Application: H-L-Photo-Proline HCl is a diazirine-containing proline  amino acid and multifunctional probe building blocks . Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907324 .

Product can be used with our line of photoreactors : Including Penn PhD (Z744035 ) & SynLED 2.0 (Z744080 )
Other Notes: Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis 

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs) 
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352101

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