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Fmoc-L-Photo-Phe-OH

ALDRICH/907294 - ≥95%

Synonym: (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)propanoic acid; N-α-(9-Fluorenylmethyloxycarbonyl)-4-(trifluoromethyldiazirin)-L-phenylalanine; Diazirine amino acid; Fmoc-Tdf-OH; Photo-Phe; Photo-crosslinking amino acid; Photoprobe building block

CAS Number: 133342-64-0
Empirical Formula (Hill Notation): C26H20F3N3O4
Molecular Weight: 495.45
MDL Number: MFCD30187628
Linear Formula: C26H20F3N3O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-907294-50MG 50 mg
 $738.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 907294-50MG.

 

application(s) peptide synthesis
assay ≥95%
form powder
functional group Fmoc
reaction suitability reaction type: Fmoc solid-phase peptide synthesis
storage temp. −20°C
Application: Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine  amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks  will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.

Product can be used with our line of photoreactors : Including Penn PhD (Z744035 ) & SynLED 2.0 (Z744080 )
Other Notes: Covalent modifier-type aggregation inhibitor of amyloid-β based on a cyclo-KLVFF motif 

Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry 

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation 

Simple and Versatile Method for Tagging Phenyldiazirine Photophores 

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis 

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs) 
WGK Germany WGK 3
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352209

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