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(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol

ALDRICH/907308 - ≥95%

Synonym: Hydroxyl diazirine difluoro TIPS-alkyne; MI-PAL; Minimally interfering photoaffinity label; Photo-click tag; Probe building block

CAS Number: 2227014-08-4
Empirical Formula (Hill Notation): C14H24F2N2OSi
Molecular Weight: 302.44
Linear Formula: C14H24F2N2OSi
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-907308-50MG 50 mg
 $295.00
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assay ≥95%
availability available only in USA
form liquid
storage temp. −20°C
Application: (3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol is a minimally interfering photo-affinity label (MI-PAL). Photoaffinity labeling is of growing interest in chemical biology and drug discovery research to characterize the non-covalent interactome and is used in protein profiling; the study of protein-protein interactions and complexes; and target engagement, identification, or validation studies. This MI-PAL contains a diazirine for UV light-induced (∼365 nm) covalent modification of a biological target with potential for downstream applications via the click chemistry-enabling alkyne tag. Its small size exhibits minimal perturbation of the interactions between proteins and the ligand or probe. The Woo lab demonstrated the electronic tuning of this MI-PAL with the placement of stability-imparting fluorine groups adjacent to the diazirine and alkyne. The alkyl fluorine ion losses are also a useful marker in collision-induced dissociation (CID) mass spectrometry experiments. Use alone or in parallel with other multi-functional building blocks  to discover the optimal probe for your chemical biology experiments.
Other Notes: Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small moleculeeprotein interactions 
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352200

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