Advanced Search



Trimethyl(trifluoromethyl)silane solution

ALDRICH/91862 - 2 M in THF

Synonym: (Trifluoromethyl)trimethylsilane; Ruppert′s reagent; Ruppert-Prakash reagent; TFMTMS; Trifluoromethyltrimethylsilane

CAS Number: 81290-20-2
Empirical Formula (Hill Notation): C4H9F3Si
Molecular Weight: 142.19
MDL Number: MFCD00145454
Linear Formula: (CH3)3SiCF3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-91862-10ML 10 mL
 $63.40
1/EA		 Add To Favorites
45-91862-50ML 50 mL
 $220.00
1/EA		 Add To Favorites

 

concentration 2 M in THF
density 0.91 g/mL at 20 °C
form liquid
InChI 1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
InChI key MWKJTNBSKNUMFN-UHFFFAOYSA-N
IVD for in vitro diagnostic use
reaction suitability reaction type: C-C Bond Formation
refractive index n20/D 1.386
SMILES string C[Si](C)(C)C(F)(F)F
Application: Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists

• Used as difluorocarbene source
Application: TMSCF3 can be used as a reagent for:
• Conversion of aromatic aldehydes to difluoromethylated products.
• C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:
• Non-activated aldimines.
• Heterocumulenes.
• Azomethine imines.
General description: Trimethyl(trifluoromethyl)silane (TMSCF3) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.
Packaging: 10, 50 mL in glass bottle
Density 0.91 g/mL at 20 °C
Refractive Index n20/D 1.386
UNSPSC 12352101

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top