2,6-Di-tert-butyl-4-methylphenol

ALDRICH/B1378 - ≥99.0% (GC), powder

Synonym: 2,6-Di-tert-butyl-p-cresol; BHT; Butylated hydroxytoluene; Butylhydroxytoluene; DBPC

CAS Number: 128-37-0
Empirical Formula (Hill Notation): C₁₅H₂₄O
Molecular Weight: 220.35
EC Number: 204-881-4
MDL Number: MFCD00011644
Linear Formula: [(CH₃)₃C]₂C₆H₂(CH₃)OH
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-B1378-100G	100 g	$32.20 1/EA	Add To Favorites
45-B1378-500G	500 g	$48.60 1/EA	Add To Favorites
45-B1378-1KG	1 kg	$82.80 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.

This image depicts SKU: B1378-100G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (GC)
autoignition temp.	878 °F
bp	265 °C (lit.)
form	powder
InChI	1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChI key	NLZUEZXRPGMBCV-UHFFFAOYSA-N
mp	69-73 °C (lit.)
Quality Level	200
SMILES string	Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
solubility	ethanol: 100 mg/mL
	vegetable oils: soluble
vapor density	7.6 (vs air)
vapor pressure	<0.01 mmHg ( 20 °C)

Application:	Thermal decomposition characteristics of BHT and its peroxide (BHTOOH): BHT is highlighted for its excellent antioxidant properties, which degrade into BHTOOH under specific conditions (S Dai, et al., 2024 ). Relaxation mechanisms in low-stress polymer networks: BHT is utilized in polymer networks to assess its effects on the mechanical properties and durability of dental composites (SH Lewis, et al., 2024 ). Compatibility and safety of labels for pharmaceutical packaging: The study found BHT in labels, indicating its widespread use in pharmaceutical packaging due to its stabilizing properties (C Fu, et al., 2023 ).
Biochem/physiol Actions:	Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
Packaging:	1 kg in poly bottle
Packaging:	100, 500 g in poly bottle

Symbol	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273 - P391 - P501
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 2
Flash Point(F)	260.6 °F - open cup
Flash Point(C)	127 °C - open cup

Purity	≥99.0% (GC)
bp	265 °C (lit.)
mp	69-73 °C (lit.)
UNSPSC	12352100

To Order From a Quote