Diethyl phosphite
ALDRICH/D99234 - 98%
Synonym: Diethoxyphosphine oxide; Diethyl acid phosphite; Diethyl hydrogen phosphite; Diethyl phosphonate; Hydrogen diethyl phosphite
CAS Number: 762-04-9
Empirical Formula (Hill Notation): C4H11O3P
Molecular Weight: 138.10
EC Number: 212-091-6
MDL Number: MFCD00044573
Linear Formula: (C2H5O)2P(O)H
Product Type: Chemical
| assay | 98% |
| bp | 50-51 °C/2 mmHg (lit.) |
| density | 1.072 g/mL at 25 °C (lit.) |
| form | liquid |
| InChI | 1S/C4H11O3P/c1-3-6-8(5)7- |
| InChI key | MJUJXFBTEFXVKU-UHFFFAOYSA |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | [H]P(=O)(OCC)OCC |
| Application: | Applications of diethyl phosphite (DEP): • It can undergo condensation with aldehydes or ketones and an amine to form α-aminophosphonates under solvent-free and catalyst-free conditions. • Reduction of gem-dibromo derivatives using diethyl phosphite in the presence of triethylamine gives monobromocyclopropanes. • Along with 4-dimethylaminopyridine, it can be used as a ligand for nickel-catalyzed cross-coupling of aryl and heteroaryl bromides, chlorides or sulfonates with arylzinc reagents. • It can be used for the catalytic asymmetric hydrophosphonylation of enones in the presence of a dinuclear zinc complex to form γ-oxo-phosphonates. • DEP can undergo Michael addition to α,β-unsaturated malonates to form β-phosphonomalonates in the presence of recyclable nano γ-ferric oxide-pyridine based catalyst. |
| General description: | Diethyl phosphite is the organophosphorus compound used as a phosphorylating agent in organic synthesis. |
| Packaging: | 250 g in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H317 - H318 |
| Precautionary statements | P261 - P272 - P280 - P302 + P352 - P305 + P351 + P338 - P333 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Purity | 98% |
| bp | 50-51 °C/2 mmHg (lit.) |
| Density | 1.072 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352100 |