Hexamethylphosphoramide
ALDRICH/H11602 - 99%
Synonym: HMPA; Hexamethylphosphoric acid triamide; Tris(dimethylamino)
CAS Number: 680-31-9
Empirical Formula (Hill Notation): C6H18N3OP
Molecular Weight: 179.20
EC Number: 211-653-8
MDL Number: MFCD00008303
Linear Formula: [(CH3)2N]3PO
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H11602-100G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H11602-500G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: H11602-5G.
| assay | 99% |
| bp | 230-232 °C/740 mmHg (lit.) |
| density | 1.03 g/mL at 25 °C (lit.) |
| InChI | 1S/C6H18N3OP/c1-7(2)11(10 |
| InChI key | GNOIPBMMFNIUFM-UHFFFAOYSA |
| mp | 7 °C (lit.) |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | CN(C)P(=O)(N(C)C)N(C)C |
| vapor density | 6.18 (vs air) |
| vapor pressure | 0.07 mmHg ( 25 °C) |
| Application: | Hexamethylphosphoramide can be used as a solvent: • For the conversion of carboxylate salt into esters by reacting with alkyl halides. • To synthesize aryl thioethers via nucleophilic displacement of unactivated aryl halides by thiolate ions. • To synthesize polyazomethines (PAZs) from dialdehyde and diamine via high-temperature solution polycondensation. |
| General description: | Hexamethylphosphoramide is a polar aprotic solvent. |
| Packaging: | 2.5 kg in glass bottle |
| Packaging: | 5, 100, 500 g in glass bottle |
| Symbol |   GHS05,GHS08 |
| Signal word | Danger |
| Hazard statements | H314 - H340 - H350 |
| Precautionary statements | P201 - P202 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 45-46 |
| Safety Statements | 53-45 |
| RIDADR | UN 3082 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 291.2 °F - closed cup |
| Flash Point(C) | 144 °C - closed cup |
| Purity | 99% |
| bp | 230-232 °C/740 mmHg (lit.) |
| mp | 7 °C (lit.) |
| Density | 1.03 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352111 |