Cap 1
ALDRICH/L040150
Synonym: Cap A
Product Type: Chemical
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| color | clear |
| form | liquid |
| impurities | ≤200 ppm water content (Karl Fischer) |
| product line | Proligo Reagents |
| storage condition | dry at room temperature |
| storage temp. | room temp |
| suitability | conforms to structure (GC, Formulation) |
| technique(s) | DNA synthesis: suitable |
| type | for DNA synthesis |
| Application: | Cap 1 is suitable for use after the phosphoramidite reaction/coupling step. |
| Biochem/physiol Actions: | Cap 1 solution aborts chains bearing unreacted 5′hydroxyl groups due to failure of reaction with activated phosphoramidite (typically, 1 to 2% of growing oligonucleotide chains in each synthesis cycle). These unreacted 5′hydroxyl groups are capped with an acetyl group and thus rendered unreactive for subsequent synthesis steps. |
| General description: | Cap 1 solution consists of n-methylimidazole, lutidine, and acetonitrile (ACN). |
| Preparation Note: | Acetonitrile / Lutidine / N-Methylimidazole 8/1/1 (v/v/v) |
| Symbol |    GHS02,GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H225 - H302 + H312 + H332 - H314 |
| Precautionary statements | P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
| Hazard Codes | F,C |
| Risk Statements | 11-20/21/22-34 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | UN 2924 8(3) / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 35.6 °F |
| Flash Point(C) | 2 °C |
| Storage Temp. | room temp |
| UNSPSC | 12352106 |