Methyl chloroformate
ALDRICH/M35304 - 99%
Synonym: MCF; Chloroformic acid methyl ester
CAS Number: 79-22-1
Empirical Formula (Hill Notation): C2H3ClO2
Molecular Weight: 94.50
EC Number: 201-187-3
MDL Number: MFCD00000639
Linear Formula: ClCOOCH3
Product Type: Chemical
| assay | 99% |
| autoignition temp. | 905 °F |
| bp | 70-72 °C (lit.) |
| density | 1.223 g/mL at 25 °C (lit.) |
| InChI | 1S/C2H3ClO2/c1-5-2(3)4/h1 |
| InChI key | XMJHPCRAQCTCFT-UHFFFAOYSA |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | COC(Cl)=O |
| storage temp. | 2-8°C |
| vapor density | 3.26 (vs air) |
| vapor pressure | 4.8 psi ( 20 °C) |
| Application: | Methyl chloroformate (MCF) is generally used for the derivatization of functional groups such as carboxylic acids, amines, and phenols. MCF can also be used: • To activate 3-acylpyridines for nucleophilic addition with alkynyltin reagents to form 2,3-disubstituted 1,2-dihydropyridines. • Chloroesterification of terminal alkynes to form β-chloro-α,β-unsaturated esters. • As an electrophilic reagent to mediate the reaction of pyridine with lithium dialkyl- or diarylcuprates to form 4-substituted 1,4-dihydropyridine derivatives. • To convert nitronates into methoxycarbonyl nitronates. |
| Packaging: | 100, 500 g in Sure/Seal™ |
| Packaging: | 5 g in glass bottle |
| Symbol |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225 - H302 + H312 - H314 - H330 |
| Precautionary statements | P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 + P310 |
| Hazard Codes | F,T+ |
| Risk Statements | 11-21/22-26-34 |
| Safety Statements | 14-26-28-36/37/39-45-46-63 |
| RIDADR | UN1238 - class 6.1 - PG 1 - Methyl chloroformate |
| WGK Germany | WGK 2 |
| Flash Point(F) | 50.0 °F - closed cup |
| Flash Point(C) | 10 °C - closed cup |
| Purity | 99% |
| bp | 70-72 °C (lit.) |
| Density | 1.223 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352100 |