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3-Nitrophenylhydrazine hydrochloride

ALDRICH/N21804 - 98%

Synonym: (3-Nitrophenyl)hydrazine hydrochloride; 1-(3-Nitrophenyl)hydrazine hydrochloride; 3-Nitrophenylhydrazine monohydrochloride; m-Nitrophenylhydrazine hydrochloride

CAS Number: 636-95-3
Empirical Formula (Hill Notation): C6H7N3O2 · HCl
Molecular Weight: 189.60
EC Number: 211-270-6
MDL Number: MFCD00012939
Linear Formula: O2NC6H4NHNH2 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-N21804-5G 5 g
 $52.20
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45-N21804-25G 25 g
 $155.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N21804-5G

 

assay 98%
form powder
InChI 1S/C6H7N3O2.ClH/c7-8-5-2-1-3-6(4-5)9(10)11;/h1-4,8H,7H2;1H
InChI key BKOYKMLGFFASBG-UHFFFAOYSA-N
mp 210 °C (dec.) (lit.)
SMILES string Cl.NNc1cccc(c1)[N+]([O-])=O
Application: <ul>
<li><strong>Derivatization agent in analytical chemistry:</strong> 3-Nitrophenylhydrazine hydrochloride is employed as a derivatization agent for the determination of gamma-Hydroxybutyric acid in biological samples infected with Herpes Simplex Virus-Type 1, utilizing LC-MRM-MS techniques, providing enhanced detection capabilities in forensic and clinical toxicology (Osinaga et al., 2022).</A></li>
<li><strong>Residual analysis in pharmaceutical formulations:</strong> This compound is also used for the quantitative analysis of residual 4-nitrobenzaldehyde in chloramphenicol and its pharmaceutical formulations, employing HPLC with UV/Vis detection after derivatization with 3-nitrophenylhydrazine, offering a reliable method for ensuring the purity and safety of pharmaceutical products (Luo et al., 2018).</A></li>
<li><strong>Forensic application in decomposition analysis:</strong> Used to derivatized the blood samples collected at the time of forensic autopsy (Matoba et al., 2022).</A></li>
</ul>
General description: 3-Nitrophenylhydrazine (3-NPH) is a derivatizing reagent used for the derivatization of carboxyl- and carbonyl-containing metabolites. This compound is also used as a high-efficiency chemical isotope-labeling reagent. Additionally, 3-nitrophenylhydrazine undergoes a condensation reaction with substituted benzaldehydes resulting in the formation of a series of ten substituted (E)-1-benzylidene-2-(3-nitrophenyl) hydrazine compounds.
Packaging: 5, 25 g in glass bottle
Purity 98%
mp 210 °C (dec.) (lit.)
UNSPSC 12352100

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