Poly(D,L-lactide-co-glycolide)

ALDRICH/P2066 - lactide:glycolide 65:35, M_w 40,000-75,000

Synonym: Lactel^® B6001-1; PLGA

MDL Number: MFCD00131930
Linear Formula: [C₃H₄O₂]_x[C₂H₂O₂]_y
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P2066-1G	1 g	$112.00 1/EA	Add To Favorites
45-P2066-5G	5 g	$387.00 1/EA	Add To Favorites

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This image depicts SKU: P2066-1G

Properties
Descriptions
Safety Info.
Basic Data

feed ratio	lactide:glycolide 65:35
form	pellets
InChI	1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
InChI key	XBBVURRQGJPTHH-UHFFFAOYSA-N
mol wt	M_w 40,000-75,000
Quality Level	100
SMILES string	OCC(O)=O.CC(O)C(O)=O
storage temp.	−20°C

Application:	Inhaled Macrophage Apoptotic Bodies-Engineered Microparticle Enabling Construction of Pro-Regenerative Microenvironment to Fight Hypoxic Lung Injury in Mice.: This study demonstrates the use of Poly(ᴅ,ʟ-lactide-co-glycolide) (PLGA) in engineering microparticles that promote lung tissue regeneration in hypoxic conditions, highlighting its potential in developing advanced therapeutic strategies for respiratory injuries (Liu et al., 2024 ). Engineered nanoparticles promote cardiac tropism of AAV vectors.: The research explores the role of PLGA nanoparticles in enhancing the targeting efficiency of AAV vectors to cardiac tissues, showcasing its application in gene therapy and cardiovascular disease treatment (Switala et al., 2024 ). Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces.: This article reports the development of drug-loaded PLGA microparticles designed to prevent biofilm formation on oral surfaces, demonstrating the polymer′s utility in dental applications and biofilm-associated infections (Oh et al., 2024 ). Dual-layer conduit containing VEGF-A - Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis.: PLGA-based dual-layer conduits are utilized to support nerve regeneration by enhancing angiogenesis, indicating its importance in neuroregenerative medicine and peripheral nerve injury treatments (Huang et al., 2024 ). Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.: The study highlights the dual-targeting capability of PLGA nanoparticles in delivering chemotherapy drugs to both tumor cells and the surrounding supportive stroma, emphasizing its role in advanced cancer therapies (He et al., 2024 ).
Features and Benefits:	Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.
Legal Information:	Lactel is a registered trademark of Evonik Corp
Packaging:	1, 5 g in poly bottle
Physical form:	Biocompatible, biodegradable polymer.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12162002

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