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Biotin-dPEG®12-TFP ester

ALDRICH/QBD10008

Synonym: Polyethylene glycol

Empirical Formula (Hill Notation): C43H69F4N3O16S
Molecular Weight: 992.08
Linear Formula: C43H69F4N3O16S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-QBD10008-100MG 100 mg
 $218.00
1/EA		 Add To Favorites
45-QBD10008-1000MG 1000 mg
 $1470.00
1/EA		 Add To Favorites

 

assay >90%
form solid or viscous liquid
InChI 1S/C43H69F4N3O16S/c44-33-31-34(45)40(47)42(39(33)46)66-38(52)5-7-54-9-11-56-13-15-58-17-19-60-21-23-62-25-27-64-29-30-65-28-26-63-24-22-61-20-18-59-16-14-57-12-10-55-8-6-48-37(51)4-2-1-3-36-41-35(32-67-36)49-43(53)50-41/h31,35-36,41H,1-30,32H2,(H,48,51)(H
InChI key YQTIPJSYUMZZNU-UHFFFAOYSA-N
polymer architecture shape : linear
functionality : monofunctional
reaction suitability reaction type: Biotinylations
  reaction type: Biotinylations
reactivity: amine reactive
  reagent type: cross-linking reagent
shipped in ambient
SMILES string O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCCC1C2NC(NC2CS1)=O)=O)OC3=C(C(F)=CC(F)=C3F)F
storage temp. −20°C
Features and Benefits: Biotin-dPEG®12-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety whcih hydrolyze more slowly than NHS esters in aqueous media and is more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®12-TFP ester has a long spacer of precise length (47.6 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin.
Legal Information: dPEG is a registered trademark of Quanta BioDesign
Legal Information: Products Protected under U.S. Patents # 7,888,536 B2
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >90%
Storage Temp. −20°C
UNSPSC 12352108

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