Biotin-dPEG®4-TFP ester
ALDRICH/QBD10009
Synonym: Polyethylene glycol
Empirical Formula (Hill Notation): C27H37F4N3O8S
Molecular Weight: 639.66
Linear Formula: C27H37F4N3O8S
Product Type: Chemical
| assay | >90% |
| form | solid or viscous liquid |
| polymer architecture | shape : linear functionality : monofunctional |
| reaction suitability | reaction type: Biotinylations |
| reaction type: Biotinylations reactivity: amine reactive |
|
| reagent type: cross-linking reagent | |
| shipped in | ambient |
| SMILES string | O=C(CCCCC1SCC(N2)C1NC2=O) |
| storage temp. | −20°C |
| Application: | Biotin-dPEG®4-TFP ester is an amphiphilic and hydrolytically stable compound used as a cross-linking reagent in biotinylations reactions. |
| Features and Benefits: | Biotin-dPEG®4-TFP ester has 2,3,5,6-tetrafluorophenyl (TFP) moiety which hydrolyzes more slowly than NHS ester in aqueous media and are more reactive towards amines than NHS esters. The single molecular weight Biotin-dPEG®4-TFP ester has a long spacer of precise length (19.2 Å) between the biotin moiety and the labeled molecule. This dPEG spacer imparts a high degree of water solubility to the biotin label. The PEG spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patents # 7,888,536 B2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |