dPEG®8-SATA (S-acetyl-dPEG®8-NHS ester)
ALDRICH/QBD10184
Synonym: Polyethylene glycol
CAS Number: 1070798-99-0
Empirical Formula (Hill Notation): C25H43NO13S
Molecular Weight: 597.67
MDL Number: MFCD11041104
Linear Formula: C25H43NO13S
Product Type: Chemical
| assay | >90% |
| form | solid or viscous liquid |
| polymer architecture | shape : linear functionality : monofunctional |
| reaction suitability | reagent type: chemical modification reagent |
| reagent type: cross-linking reagent reactivity: amine reactive |
|
| shipped in | ambient |
| SMILES string | O=C(ON1C(CCC1=O)=O)CCOCCO |
| storage temp. | −20°C |
| Features and Benefits: | dPEG®8-SATA (S-acetyl-dPEG®8-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG®8-SATA to install a protected thiol connected to the molecule via the dPEG® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patents # 7,888,536 B2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |