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NHS-S-S-dPEG®4-biotin (cleavable)

ALDRICH/QBD10194

Synonym: 2,5-Dioxo-1-pyrrolidinyl 29-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-9,25-dioxo-12,15,18,21-tetraoxa-4,5-dithia-8,24-diazanonacosanoate; Polyethylene glycol

CAS Number: 1260247-51-5
Empirical Formula (Hill Notation): C30H49N5O11S3
Molecular Weight: 751.93
Linear Formula: C30H49N5O11S3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-QBD10194-50MG 50 mg
 $259.00
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45-QBD10194-500MG 500 mg
 $1270.00
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assay >90%
form solid or viscous liquid
functional group disulfide
InChI 1S/C30H49N5O11S3/c36-24(4-2-1-3-23-29-22(21-47-23)33-30(41)34-29)31-9-12-43-14-16-45-18-17-44-15-13-42-11-7-25(37)32-10-20-49-48-19-8-28(40)46-35-26(38)5-6-27(35)39/h22-23,29H,1-21H2,(H,31,36)(H,32,37)(H2,33,34,41)
InChI key QEVJWOMRMWJABZ-UHFFFAOYSA-N
polymer architecture shape : linear
functionality : monofunctional
reaction suitability reaction type: Biotinylations
  reagent type: cross-linking reagent
shipped in ambient
SMILES string O=C(NCCSSCCC(ON1C(CCC1=O)=O)=O)CCOCCOCCOCCOCCNC(CCCCC2C3NC(NC3CS2)=O)=O
storage temp. −20°C
Features and Benefits: NHS-S-S-dPEG®4-biotin is used extensively to label molecules that contain a free amine with biotin. This dPEG® spacer imparts a high degree of water solubility to the biotin label. For biotinylated peptides and proteins, the dPEG® spacer dramatically reduces aggregation and precipitation of the modified molecule and reduces non-specific binding of the molecule, both of which are common problems with molecules that have been biotinylated with the widely used NHS-LC-biotin. NHS-S-S-dPEG®4-biotin contains a disulfide group in the linear chain, allowing the biotin to be cleaved reductively from the labeled molecule.
Legal Information: dPEG is a registered trademark of Quanta BioDesign
Legal Information: Products Protected under U.S. Patents # 7,888,536 B2
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >90%
Storage Temp. −20°C
UNSPSC 51171641

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