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dPEG®4-biotin acid

ALDRICH/QBD10199 - >95% (HPLC)

Synonym: Biotin-PEG-acid; Biotin-PEG4-COOH; Biotin-PEG4-acid; Carboxy-PEG4-biotin; PEG4-biotin acid

Empirical Formula (Hill Notation): C21H37N3O8S
Molecular Weight: 491.60
Linear Formula: C21H37N3O8S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-QBD10199-100MG 100 mg
 $170.00
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assay >95% (HPLC)
form solid or viscous liquid
polymer architecture shape : linear
functionality : monofunctional
reaction suitability reaction type: Biotinylations
  reaction type: Pegylations
shipped in ambient
storage temp. −20°C
Features and Benefits: dPEG4 biotin acid consists of biotin and a propionic acid-functionalized tetraethylene glycol derivative. Numerous functional or reactive groups can modify the terminal acid moiety, including the acylating agents N-hydroxysuccinimide (NHS) and 2,3,5,6-tetrafluorophenol (TFP). Also, dPEG4 biotin acid reacts directly with primary amines using a suitable carbodiimide such as 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC). The amphiphilic dPEG linker gives biotin excellent solubility in water and aqueous buffer, where biotin usually is poorly soluble. dPEG4 biotin acid offers significantly superior solubility and performance characteristics compared to the traditional, highly hydrophobic biotinylation reagent known as LC-biotin. Moreover, although dPEG4 biotin acid and LC-biotin have comparable linker lengths, dPEG4 biotin acid will not trigger the aggregation and precipitation of conjugated biomolecules, even at high levels of biotin incorporation on the biomolecule. In contrast, LC-biotin triggers the aggregation and precipitation of biomolecules with the incorporation of a few LC-biotin groups onto the biomolecule.
Legal Information: dPEG is a registered trademark of Quanta BioDesign
Legal Information: Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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