Fmoc-N-amido-dPEG®8-acid
ALDRICH/QBD10273 - >95% (HPLC)
Synonym: Fmoc-N-amido-PEG8-COOH; Fmoc-N-amido-PEG8-acid; Fmoc-NH-PEG8-acid; Fmoc-PEG-acid
Empirical Formula (Hill Notation): C34H49NO12
Molecular Weight: 663.75
MDL Number: MFCD11041143
Linear Formula: C34H49NO12
Product Type: Chemical
| assay | >95% (HPLC) |
| form | solid or viscous liquid |
| polymer architecture | shape : linear functionality : heterobifunctional |
| reaction suitability | reaction type: Pegylations |
| shipped in | ambient |
| storage temp. | −20°C |
| Features and Benefits: | Fmoc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEGn-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681 |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |