SPDP-dPEG®8-NHS ester
ALDRICH/QBD10376
CAS Number: 1252257-56-9
Empirical Formula (Hill Notation): C31H49N3O13S2
Molecular Weight: 735.86
MDL Number: MFCD13185003
Linear Formula: C31H49N3O13S2
Product Type: Chemical
| assay | >90% |
| form | solid or viscous liquid |
| functional group | NHS ester |
| polymer architecture | shape : linear functionality : heterobifunctional |
| reaction suitability | reactivity: thiol reactive |
| reagent type: cross-linking reagent reactivity: amine reactive |
|
| shipped in | ambient |
| SMILES string | O=C(NCCOCCOCCOCCOCCOCCOCC |
| storage temp. | −20°C |
| Features and Benefits: | SPDP-dPEG®8-NHS ester has an amine-reactive N-hydroxysuccinimide (NHS) ester at one end and a sulfhydryl-reactive 2-pyridyldithiol group at the opposite end. This has a single molecular weight PEG spacer arm, which confers greater water solubility to the crosslinker and linked proteins compared to crosslinkers having only hydrocarbon spacers. Protein aggregation and precipitation also are greatly reduced with SPDP-dPEG crosslinkers compared to crosslinkers that have only hydrocarbon spacers. dPEG spacer of specific length (37.2 Å) provides precise distance control between the SPDP moiety and the target molecule. Pyridyldithiol reagents produce disulfide-containing linkages that can be cleaved with reducing agents such as dithiothreitol (DTT). Crosslinking experiments with SPDP reagents are not limited to those involving proteins. Any of a variety of molecules with primary amines and sulfhydryl groups can be modified or crosslinked using SPDP reagents. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patents # 7,888,536 B2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |