MAL-dPEG®4-TFP ester
ALDRICH/QBD10551
Empirical Formula (Hill Notation): C24H28F4N2O9
Molecular Weight: 564.48
MDL Number: MFCD28505515
Linear Formula: C24H28F4N2O9
Product Type: Chemical
assay | >90% |
form | solid or viscous liquid |
polymer architecture | shape : linear functionality : heterobifunctional |
reaction suitability | reagent type: cross-linking reagent reactivity: amine reactive |
reagent type: cross-linking reagent reactivity: thiol reactive |
|
shipped in | ambient |
SMILES string | O=C(NCCOCCOCCOCCOCCC(OC1= |
storage temp. | −20°C |
Features and Benefits: | MAL-dPEG®4-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo. |
Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
Legal Information: | Products Protected under U.S. Patents # 7,888,536 B2 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >90% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |