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MAL-dPEG®4-TFP ester

ALDRICH/QBD10551

Synonym: Polyethylene glycol

Empirical Formula (Hill Notation): C24H28F4N2O9
Molecular Weight: 564.48
MDL Number: MFCD28505515
Linear Formula: C24H28F4N2O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-QBD10551-100MG 100 mg
 $315.00
1/EA		 Add To Favorites
45-QBD10551-1000MG 1000 mg
 $386.00
1/EA		 Add To Favorites

 

assay >90%
form solid or viscous liquid
functional group ester
  maleimide
InChI 1S/C24H28F4N2O9/c25-16-15-17(26)23(28)24(22(16)27)39-21(34)4-7-35-9-11-37-13-14-38-12-10-36-8-5-29-18(31)3-6-30-19(32)1-2-20(30)33/h1-2,15H,3-14H2,(H,29,31)
InChI key LKZRDWRFDOPKGN-UHFFFAOYSA-N
polymer architecture shape : linear
functionality : heterobifunctional
reaction suitability reactivity: thiol reactive
  reagent type: cross-linking reagent
reactivity: amine reactive
shipped in ambient
SMILES string O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O
storage temp. −20°C
Features and Benefits: MAL-dPEG®4-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.
Legal Information: dPEG is a registered trademark of Quanta BioDesign
Legal Information: Products Protected under U.S. Patents # 7,888,536 B2
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >90%
Storage Temp. −20°C
UNSPSC 12352108

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