MAL-dPEG®8-TFP ester
ALDRICH/QBD10552
Synonym: Polyethylene glycol
Empirical Formula (Hill Notation): C32H44F4N2O13
Molecular Weight: 740.69
MDL Number: MFCD28505514
Linear Formula: C32H44F4N2O13
Product Type: Chemical
| assay | >90% |
| form | solid or viscous liquid |
| functional group | ester |
| maleimide | |
| polymer architecture | shape : linear functionality : heterobifunctional |
| reaction suitability | reactivity: thiol reactive |
| reagent type: cross-linking reagent reactivity: amine reactive |
|
| shipped in | ambient |
| SMILES string | O=C(OC1=C(F)C(F)=CC(F)=C1 |
| storage temp. | −20°C |
| Features and Benefits: | MAL-dPEG®8-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patents # 7,888,536 B2 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |