t-Boc-N-amido-dPEG®8-acid
ALDRICH/QBD10760 - >95% (HPLC)
Synonym: t-Boc-N-amido-PEG8-COOH; t-Boc-N-amido-PEG8-acid; t-Boc-PEG-acid; BocNH-PEG8-CH2CH2COOH
Empirical Formula (Hill Notation): C24H47NO12
Molecular Weight: 541.63
MDL Number: MFCD13185254
Linear Formula: C24H47NO12
Product Type: Chemical
assay | >95% (HPLC) |
form | solid or viscous liquid |
polymer architecture | shape : linear functionality : heterobifunctional |
reaction suitability | reaction type: Pegylations |
shipped in | ambient |
storage temp. | −20°C |
Features and Benefits: | t-Boc-N-amido-dPEG8-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atoms-long dPEG spacer allows the introduction of a short, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEGn-acid (n=4, 8, 12, 24, 36) product series. |
Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
Legal Information: | Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | >95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |