m-dPEG®37-NHS ester
ALDRICH/QBD10910 - >95% (HPLC)
Synonym: m-PEG37-NHS ester; mPEG-NHS ester; mPEG1500-NHS ester; mPEG37-NHS ester
Empirical Formula (Hill Notation): C80H155NO41
Molecular Weight: 1787.07
MDL Number: MFCD21363217
Linear Formula: C80H155NO41
Product Type: Chemical
| assay | >95% (HPLC) |
| form | solid or viscous liquid |
| polymer architecture | shape : linear functionality : monofunctional |
| reaction suitability | reaction type: Pegylations |
| shipped in | ambient |
| storage temp. | −20°C |
| Features and Benefits: | m-dPEG37-NHS ester is a methyl-terminated, single molecular weight, discrete chain length polyethylene glycol (dPEG) spacer. The carboxylic acid moiety on the end of the molecule opposite the methyl cap is activated with N-hydroxysuccinimide (NHS) for facile reaction with free amines. The dPEG spacer is 112 atoms (133.9 Å) long, a monodisperse equivalent of a polymeric PEG1500. m-dPEG37-NHS ester can be used to modify silica shelled quantum dots to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Overall, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, and improved PK and BD properties. |
| Legal Information: | dPEG is a registered trademark of Quanta BioDesign |
| Legal Information: | Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681 |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | >95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |