Phthalimidooxy-dPEG^®₁₂-NHS ester

ALDRICH/QBD11135

Empirical Formula (Hill Notation): C₃₉H₆₀N₂O₁₉
Molecular Weight: 860.90
MDL Number: MFCD21363338
Linear Formula: C₃₉H₆₀N₂O₁₉
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-QBD11135-100MG	100 mg	$361.00 1/EAAdd To Favorites		Add To Favorites

assay	>90%
form	solid or viscous liquid
polymer architecture	shape : linear functionality : heterobifunctional
reaction suitability	reactivity: thiol reactive
	reagent type: cross-linking reagent reactivity: amine reactive
shipped in	ambient
SMILES string	O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCON1C(C2=C(C1=O)C=CC=C2)=O)ON3C(CCC3=O)=O
storage temp.	−20°C

Features and Benefits:	Phthalimidooxy-dPEG^®₁₂-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.
Legal Information:	dPEG is a registered trademark of Quanta BioDesign
Legal Information:	Products Protected under U.S. Patents # 7,888,536 B2