Synonym: 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride; THIP hydrochloride
CAS Number: 85118-33-8
Empirical Formula (Hill Notation): C6H8N2O2 · HCl
Molecular Weight: 176.60
EC Number: 285-687-7
MDL Number: MFCD00055180
Linear Formula: C6H8N2O2 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
solid |
| InChI |
1S/C6H8N2O2.ClH/c9-6-4-1-2-7-3-5(4)10-8-6;/h7H,1-3H2,(H,8,9);1H |
| InChI key |
ZDZDSZQYRBZPNN-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
Cl[H].Oc1noc2CNCCc12 |
| solubility |
ethanol: 0.91 mg/mL |
| |
H2O: 20 mg/mL |
| storage condition |
desiccated |
| Application: |
Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration. |
| Biochem/physiol Actions: |
GABAA receptor agonist. |
| Disclaimer: |
Photosensitive |
| General description: |
Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington’s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body. |
| Packaging: |
25, 100, 500 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352100 |
