Synonym: 3,4,5-Trihydroxybenzoic acid propyl ester
CAS Number: 121-79-9
Empirical Formula (Hill Notation): C10H12O5
Molecular Weight: 212.20
EC Number: 204-498-2
MDL Number: MFCD00002196
Linear Formula: 3,4,5-(HO)3C6H2CO2CH2CH2CH3
Product Type: Chemical
| agency |
follows IFRA guidelines |
| application(s) |
flavors and fragrances |
| assay |
≥98% |
| biological source |
synthetic |
| documentation |
see Safety & Documentation for available documents |
| food allergen |
no known allergens |
| fragrance allergen |
no known allergens |
| grade |
Fragrance grade |
| |
Halal |
| |
Kosher |
| InChI |
1S/C10H12O5/c1-2-3-15-10(14)6-4-7(11)9(13)8(12)5-6/h4-5,11-13H,2-3H2,1H3 |
| InChI key |
ZTHYODDOHIVTJV-UHFFFAOYSA-N |
| mp |
146-149 °C (lit.) |
| organoleptic |
odorless |
| Quality Level |
400  |
| reg. compliance |
EU Regulation 1223/2009 |
| |
EU Regulation 1334/2008 & 178/2002 |
| |
EU Regulation 178/2002 |
| |
FCC |
| |
FDA 21 CFR 172.615 |
| |
FDA 21 CFR 175.125 |
| |
FDA 21 CFR 175.300 |
| |
FDA 21 CFR 175.380 |
| |
FDA 21 CFR 175.390 |
| |
FDA 21 CFR 184.1660 |
| SMILES string |
CCCOC(=O)c1cc(O)c(O)c(O)c1 |
| Application: |
Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein. |
| Biochem/physiol Actions: |
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. |
| Biochem/physiol Actions: |
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis. |
| General description: |
Propyl gallate is mainly used as an antioxidant for edible fats and vegetable oils. It occurs naturally in the pods of tara tree. |
| Packaging: |
1 kg in poly bottle |
| Packaging: |
10 kg in fiber drum |
| Reconstitution: |
Prepare a 0.1M solution in glycerol:PBS (9:1) |
| Purity |
≥98% |
| mp |
146-149 °C (lit.) |
| FEMA Number |
2947 |
| UNSPSC |
12164502 |
GHS05,GHS07,GHS09