2,3,5,6-Tetramethylpyrazine

ALDRICH/W323713 - natural, ≥98%, FG

Synonym: Chuanxingzine; Ligustrazine; Tetrapyrazine

CAS Number: 1124-11-4
Empirical Formula (Hill Notation): C₈H₁₂N₂
Molecular Weight: 136.19
EC Number: 214-391-2
MDL Number: MFCD00006146
Linear Formula: C₈H₁₂N₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-W323713-SAMPLE-K	1 each	$62.30 1/EA	Add To Favorites
45-W323713-100G-K	100 g	$401.00 1/EA	Add To Favorites
45-W323713-1KG-K	1 kg	$2930.00 1/EA	Add To Favorites

12 Principles of Green Chemistry: Principle 3—Less Hazardous Chemical Syntheses. This product manufacturing process was designed with lesser toxicity to human health and the environment.

12 Principles of Green Chemistry: Principle 7—A raw material or feedstock should be renewable rather than depleting whenever technically and economically practicable.

Properties
Descriptions
Safety Info.
Basic Data

agency	follows IFRA guidelines
	meets purity specifications of JECFA
application(s)	flavors and fragrances
assay	≥98%
bp	190 °C (lit.)
documentation	see Safety & Documentation for available documents
food allergen	no known allergens
fragrance allergen	no known allergens
grade	FG
	Fragrance grade
	Halal
	Kosher
	natural
greener alternative category	, Aligned
greener alternative product characteristics	Less Hazardous Chemical Syntheses Use of Renewable Feedstocks Learn more about the Principles of Green Chemistry .
impurities	≤2.0% water (Karl Fischer)
InChI	1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
InChI key	FINHMKGKINIASC-UHFFFAOYSA-N
mp	77-80 °C (lit.)
organoleptic	chocolate; coffee; fatty; musty; nutty
Quality Level	300
	400
reg. compliance	EU Regulation 1223/2009
	EU Regulation 1334/2008 & 178/2002
SMILES string	Cc1nc(C)c(C)nc1C
sustainability	Greener Alternative Product

Application:	Booklice Liposcelis bostrychophila are efficiently attracted by the combination of 2,3,5,6-tetramethylpyrazine and ultraviolet light.: This study demonstrates that the combination of 2,3,5,6-tetramethylpyrazine and ultraviolet light effectively attracts booklice, suggesting a potential application for pest management in stored product environments (Tanaka et al., 2024 ). 2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation.: The research highlights the neuroprotective effects of 2,3,5,6-tetramethylpyrazine, showing its potential in treating retinal diseases by protecting photoreceptors from stress-induced damage (Huang et al., 2021 ). Tetramethylpyrazine-Inducible Promoter Region from Rhodococcus jostii TMP1.: The study identifies a promoter region in Rhodococcus jostii TMP1 that is inducible by tetramethylpyrazine, which could be utilized in genetic engineering and biotechnology applications (Stanislauskienė et al., 2018 ).
General description:	2,3,5,6-Tetramethylpyrazine is one of the main volatile aroma compounds in roasted cocoa beans and maple syrup.
General description:	We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product is a Biobased products, showing key improvements in Green Chemistry Principles “Less Hazardous Chemical Syntheses” and “Use of Renewable Feedstock”.
Packaging:	1 kg in poly bottle
Packaging:	25, 100 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H315 - H319 - H335
Precautionary statements	P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
Hazard Codes	Xn
Risk Statements	22-37/38-41
Safety Statements	26-39
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98%
bp	190 °C (lit.)
mp	77-80 °C (lit.)
FEMA Number	3237
UNSPSC	12164502

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