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AMP-PNP

ROCHE/10102547001 - Adenylyl-imidodiphosphate

Synonym: Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate; β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate; AMP-PNP; ATP[β,γ-NH]; Adenylyl imidodiphosphate lithium salt hydrate; App(NH)p

CAS Number: 25612-73-1 (free acid)
Empirical Formula (Hill Notation): C10H17N6O12P3 · xLi+ · yH2O
Molecular Weight: 506.20 (free acid basis)
Linear Formula: C10H17N6O12P3 · xLi+ · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-10102547001 25 mg
 $239.00
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form powder
InChI 1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
InChI key PVKSNHVPLWYQGJ-KQYNXXCUSA-N
manufacturer/tradename Roche
mol wt Mr 506.2 (ANP-PNP)
  Mr 529.9 (AMP-PNP-Li4)
packaging pkg of 25 mg
Quality Level 100 
SMILES string [Li+].[Li+].[Li+].[Li+].[H]O[H].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)NP([O-])([O-])=O)[C@@H](O)[C@H]3O
Application: AMP-PNP has been used in the preparation of nucleotide solutions, two-motor fluorescence assay, preparation of flow-cells with kinesin and cascade binding assays.
Application: AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase.
AMP-PNP has been used for two-motor fluorescence assay.
Features and Benefits: Contents
88% AMP-PNP (from N), 4.5% lithium, 6% water
General description: AMP-PNP (adenylyl-imidodiphosphate) is a non-hydrolysable analogue of ATP. It inhibits fast axonal transport and facilitates the interaction between membranous organelles and microtubules.
General description: AMP-PNP(adenylyl-imidodiphosphate) is an artificial substrate of enzyme, adenylate cyclase. Adenylate cyclase helps to hydrolyze adenylyl-imidodiphosphate slowly than ATP.
Other Notes: For life science research only. Not for use in diagnostic procedures.
Quality: Contaminants: ≤1.5% Pi , <0.1% ATP (enzymatically)
Storage and Stability: Store at -15–-25 °C. (Store dry!)
RIDADR NONH for all modes of transport
WGK Germany WGK 1
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352204

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