Guanidine thiocyanate
ROCHE/11685929001
Synonym: Guanidine thiocyanate; Guanidinium rhodanide; Guanidinium thiocyanate
CAS Number: 593-84-0
Empirical Formula (Hill Notation): CH5N3 · CHNS
Molecular Weight: 118.16
MDL Number: MFCD00013027
Linear Formula: NH2C(=NH)NH2 · HSCN
Product Type: Chemical
| absorption | ≤0.10 at 300 and 410 nm in water at 6 M |
| form | solid |
| InChI | 1S/CH5N3.CHNS/c2-1(3)4;2- |
| InChI key | ZJYYHGLJYGJLLN-UHFFFAOYSA |
| manufacturer/tradename | Roche |
| mol wt | 118.16 |
| mp | 120-122 °C (lit.) |
| packaging | pkg of 500 g |
| shipped in | ambient |
| SMILES string | SC#N.NC(N)=N |
| storage temp. | 20-25°C |
| Application: | Chaotropic agent and strong denaturant; solubilizes cells. |
| Application: | Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride. |
| Application: | Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride. |
| General description: | Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers. |
| Other Notes: | For life science research only. Not for use in diagnostic procedures. |
| Physical form: | Crystals |
| Specifications: | Absorbance: A300 and A410 ≤0.10 (6 M in H2O) each Formula: CH5N3 x HSCN |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H302 + H312 + H332 - H314 - H412 |
| Precautionary statements | P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 + P310 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Supplemental Hazard Statements | EUH032 |
| mp | 120-122 °C (lit.) |
| Storage Temp. | 20-25°C |
| UNSPSC | 12352200 |