Apigenin
SIAL/01760595 - primary reference standard
Synonym: 4′,5,7-Trihydroxyflavone; 5,7-
CAS Number: 520-36-5
Empirical Formula (Hill Notation): C15H10O5
Molecular Weight: 270.24
EC Number: 208-292-3
MDL Number: MFCD00006831
Linear Formula: C15H10O5
Product Type: Chemical
application(s) | food and beverages |
grade | primary reference standard |
InChI | 1S/C15H10O5/c16-9-3-1-8(2 |
InChI key | KZNIFHPLKGYRTM-UHFFFAOYSA |
manufacturer/tradename | HWI |
mp | >300 °C (lit.) |
shelf life | limited shelf life, expiry date on the label |
SMILES string | Oc1ccc(cc1)C2=CC(=O)c3c(O |
Application: | It may be used as internal standard for determining peurarin and its metabolites, using LC-ESI-MS/MS, in blood and urine of rats. |
Biochem/physiol Actions: | A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication. |
General description: | Flavonoids belong to polyphenolic class of compounds. They play crucial role in biological activities which include tumor growth inhibition and chemoprevention. Apigenin is a plant flavonoid mostly used to inhibit ornithine decarboxylase activity and skin tumor. |
General description: | Produced and qualified by HWI pharma services GmbH. Exact content by quantitative NMR can be found on the certificate. |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | >300 °C (lit.) |
UNSPSC | 85151701 |