Docetaxel

SIAL/01885 - purum, ≥97.0% (HPLC)

Synonym: Docetaxel anhydrous

CAS Number: 114977-28-5
Empirical Formula (Hill Notation): C₄₃H₅₃NO₁₄
Molecular Weight: 807.88
MDL Number: MFCD00800737
Linear Formula: C₄₃H₅₃NO₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-01885-5MG-F	5 mg	$269.00 1/EA		Add To Favorites
45-01885-25MG-F	25 mg	$926.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.0% (HPLC)
form	powder or crystals
grade	purum
impurities	~6% water
InChI	1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
InChI key	ZDZOTLJHXYCWBA-VCVYQWHSSA-N
mp	186-192 °C (dec.)
Quality Level	200
SMILES string	[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c6ccccc6

Application:	Docetaxel has been used: • to test its effect on lysosomal autophagic flux in gastric cancer cells • in combination with stearidonic acid (SDA) to increase its efficacy and enhancing cell death in human prostate cancer cells • as a microtubule-stabilizing agent in prostate and cervical cancer cells • in combination with a γ-secretase inhibitor (GSI) in prostate cancer stem-like cells (PCSCs) to test its effect on the notch signaling pathway
Biochem/physiol Actions:	Docetaxel (DOC) is an anti-microtubule agent , a standard anti-cancer drug used in first-line chemotherapy treatment in many types of cancer including prostate and breast cancer. It elicits a stronger effect of inhibiting angiogenesis in both in vitro and in vivo by acting on vascular endothelial growth factor (VEGF) associated with tumor cells. Being involved in many key cellular processes such as cell cycle, angiogenesis, and gene expression; docetaxel interacts with many signaling pathways, such as the epidermal growth factor receptor (EGFR) pathway, Ras pathway, etc.
Biochem/physiol Actions:	Docetaxel is a taxane anti-cancer agent related to paclitaxel. It binds to and stabilizes the β−tubulin subunit of microtubules, preventing depolymerization of the mitotic spindle thus leading to cell cycle arrest and apoptosis.
General description:	Docetaxel is a cytotoxic, semisynthetic, second-generation taxane derived from the needles of the European yew tree , with a baccatin ring , and is an anthracycline antibiotic. It is related to paclitaxel but structurally it differs from paclitaxel on the 3′ position of the side chain and 10′ position of the baccatin ring.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H319 - H341 - H360D - H362 - H372
Precautionary statements	P201 - P202 - P260 - P263 - P305 + P351 + P338 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (HPLC)
mp	186-192 °C (dec.)
UNSPSC	12352200

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