N-Ethyldiisopropylamine

SIAL/03440 - BASF quality, ≥98.0%

Synonym: N,N-Diisopropylethylamine; Hünigs base

CAS Number: 7087-68-5
Empirical Formula (Hill Notation): C₈H₁₉N
Molecular Weight: 129.24
EC Number: 230-392-0
MDL Number: MFCD00008868
Linear Formula: CH₃CH₂N[CH(CH₃)₂]₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-03440-4X25ML	25 mL	$181.00 4/EA	Add To Favorites
45-03440-50ML	50 mL	$92.20 1/EA	Add To Favorites
45-03440-250ML	250 mL	$138.00 1/EA	Add To Favorites
45-03440-1L	1 L	$373.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98.0%
bp	126-128 °C (lit.)
density	0.755 g/mL at 20 °C
	0.755 g/mL at 20 °C (lit.)
	0.757 g/mL at 25 °C (lit.)
form	liquid
grade	BASF quality
impurities	≤0.5% water
InChI	1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChI key	JGFZNNIVVJXRND-UHFFFAOYSA-N
Quality Level	200
refractive index	n20/D 1.414
SMILES string	CCN(C(C)C)C(C)C

Application:

Catalytic activity in dioxygen reduction: A study utilized Mn complexes with pendent proton donor relays and added base, including N-Ethyldiisopropylamine, to control product selectivity during dioxygen reduction, providing insights into catalytic mechanisms and potential industrial applications (Cook et al., 2024 ).

Three-dimensional imaging in medical applications: N-Ethyldiisopropylamine was mentioned in the context of its role in improving the resolution of three-dimensional imaging techniques based on computed tomography angiography (CTA), crucial for preoperative perforator selection in reconstructive surgery (Su et al., 2024 ).

Synthesis of Spirocyclopropane-Containing Compounds: Research demonstrated the application of N-Ethyldiisopropylamine in the synthesis of spirocyclopropane-containing 4H-pyrazolo[1,5-a]indoles through alkylative dearomatization and intramolecular N-imination, highlighting its utility in complex organic synthesis (Huang et al., 2023 ).

General description:

N,N-Diisopropylethylamine (DIPEA), also known as Hunig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed in substitution reactions, alkylations, and amide couplings, etc. DIPEA is also used as a base in the Pd catalyzed cross-coupling reactions, which include Heck coupling and Sonagashira coupling reactions.

Symbol	GHS02,GHS05,GHS06
Signal word	Danger
Hazard statements	H225 - H302 - H318 - H331 - H335
Precautionary statements	P210 - P280 - P301 + P312 + P330 - P304 + P340 + P311 - P305 + P351 + P338 + P310
Hazard Codes	F,T
Risk Statements	11-20/22-37/38-41
Safety Statements	9-16-26-36/37/39-45
RIDADR	UN 3384 3(6.1) / PGI
WGK Germany	WGK 2
Flash Point(F)	49.1 °F
Flash Point(C)	9.5 °C

Purity	≥98.0%
bp	126-128 °C (lit.)
Density	0.755 g/mL at 20 °C (lit.); 0.755 g/mL at 20 °C; 0.757 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.414
UNSPSC	12352100

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