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3-Hydroxyglutaric acid

SIAL/04725 - analytical standard

Synonym: β-Hydroxyglutaric acid; 3-Hydroxypentanedioic acid

CAS Number: 638-18-6
Empirical Formula (Hill Notation): C5H8O5
Molecular Weight: 148.11
MDL Number: MFCD06208235
Linear Formula: C5H8O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-04725-10MG 10 mg
 $215.00
1/EA		 Add To Favorites
45-04725-50MG 50 mg
 $989.00
1/EA		 Add To Favorites

 

application(s) clinical testing
assay ≥95.0% (GC)
format neat
grade analytical standard
InChI 1S/C5H8O5/c6-3(1-4(7)8)2-5(9)10/h3,6H,1-2H2,(H,7,8)(H,9,10)
InChI key ZQHYXNSQOIDNTL-UHFFFAOYSA-N
Quality Level 100 
shelf life limited shelf life, expiry date on the label
storage temp. 2-8°C
Biochem/physiol Actions: 3-Hydroxyglutaric acid is a glutaric acid derivative which is the byproduct of glutaric acidemia type I. Glutaric aciduria type I (glutaryl-CoA dehydrogenase deficiency) is an inborn error of metabolism that usually manifests in infancy by an acute encephalopathic crisis and often results in permanent motor handicap. Studies indicate that 3-hydroxyglutaric acid can be used as biomarker for GCDH (glutaryl-CoA dehydrogenase) deficiency. It is believed that the excretion of 3-hydroxyglutaric acid is increased during ketosis, which occurs during glutaryl-CoA dehydrogenase deficiency. Studies on striatal cultures show that IGF-1 and FGF-2 (bFGF) reduces 3-hydroxyglutaric acid toxicity in striatal neurons.
Other Notes: Find a digital Reference Material for this product available on our online platform ChemisTwin®  for NMR. You can use this digital equivalent on ChemisTwin®  for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here  and start your free trial .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥95.0% (GC)
Storage Temp. 2-8°C
UNSPSC 12352106

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