Curcumin
SIAL/08511 - analytical standard
Synonym: (E,E)
CAS Number: 458-37-7
Empirical Formula (Hill Notation): C21H20O6
Molecular Weight: 368.38
EC Number: 207-280-5
MDL Number: MFCD00008365
Linear Formula: [HOC6H3(OCH3)CH=CHCO]2CH2
Product Type: Chemical
| application(s) | cleaning products cosmetics food and beverages personal care |
| assay | ≥98.0% (HPLC) |
| form | powder |
| format | neat |
| grade | analytical standard |
| InChI | 1S/C21H20O6/c1-26-20-11-1 |
| InChI key | VFLDPWHFBUODDF-FCXRPNKRSA |
| Quality Level | 100  |
| shelf life | limited shelf life, expiry date on the label |
| SMILES string | COc1cc(C=CC(=O)CC(=O)C |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor density | 13 (vs air) |
| Application: | Curcumin may be used as a reference standard for the determination of curcumin in rat plasma by high-performance liquid chromatography method. |
| Biochem/physiol Actions: | A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope. |
| General description: | Curcumin is an anti-inflammatory agent extracted from the roots of Curcuma longa Linn. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98.0% (HPLC) |
| Storage Temp. | 2-8°C |
| Colour Index Number | 75300 |
| UNSPSC | 85151701 |