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(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

SIAL/12805 - purum, ≥97.0% (TLC)

Synonym: PyBOP®

CAS Number: 128625-52-5
Empirical Formula (Hill Notation): C18H28F6N6OP2
Molecular Weight: 520.39
MDL Number: MFCD00077411
Linear Formula: C18H28N6OP · PF6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-12805-1G-F 1 g
 $0.00
1/EA
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45-12805-5G-F 5 g
 $0.00
1/EA
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45-12805-25G-F 25 g
 $307.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 12805-25G-F
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 12805-1G-F
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 12805-5G-F

 

application(s) peptide synthesis
assay ≥97.0% (TLC)
form solid
grade purum
InChI 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChI key VIAFLMPQBHAMLI-UHFFFAOYSA-N
mp 154-156 °C (dec.) (lit.)
  ~150 °C
Quality Level 200 
reaction suitability reaction type: Coupling Reactions
SMILES string F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
storage temp. 2-8°C
Application: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
• As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
• Synthesis of structured pure triacylglycerol (TAG) regioisomers.
• As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
• Synthesis of herceptin- nanoparticles.
Application: Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.
General description: (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
Legal Information: PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
Purity ≥97.0% (TLC)
mp ~150 °C; 154-156 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 12352101

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