(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

SIAL/12805 - purum, ≥97.0% (TLC)

Synonym: PyBOP^®

CAS Number: 128625-52-5
Empirical Formula (Hill Notation): C₁₈H₂₈F₆N₆OP₂
Molecular Weight: 520.39
MDL Number: MFCD00077411
Linear Formula: C₁₈H₂₈N₆OP · PF₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-12805-1G-F	1 g	$81.90 1/EA	Add To Favorites
45-12805-5G-F	5 g	$96.00 1/EA	Add To Favorites
45-12805-25G-F	25 g	$298.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 12805-25G-F

Properties
Descriptions
Safety Info.
Basic Data

application(s)	peptide synthesis
assay	≥97.0% (TLC)
form	solid
grade	purum
InChI	1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
InChI key	VIAFLMPQBHAMLI-UHFFFAOYSA-N
mp	154-156 °C (dec.) (lit.)
	~150 °C
Quality Level	200
reaction suitability	reaction type: Coupling Reactions
SMILES string	F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5
storage temp.	2-8°C

Application:	(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies: • As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates. • Synthesis of structured pure triacylglycerol (TAG) regioisomers. • As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support. • Synthesis of herceptin- nanoparticles.
Application:	Analogue of the BOP coupling reagent which does not form carcinogenic HMPA as by-product.
General description:	(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
Legal Information:	PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Symbol	GHS07,GHS09,GHS07,GHS09
Signal word	Warning-Warning
Hazard statements	H302 - H317 - H410 - H302 - H317 - H410
Precautionary statements	P261 - P264 - P273 - P280 - P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352 - P301 + P312 - P302 + P352
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (TLC)
mp	~150 °C; 154-156 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	12352101

To Order From a Quote