(+)-Bicuculline

SIAL/14340 - ≥97.0% (TLC)

Synonym: Bucuculline

CAS Number: 485-49-4
Empirical Formula (Hill Notation): C₂₀H₁₇NO₆
Molecular Weight: 367.35
EC Number: 207-619-7
MDL Number: MFCD00005006
Linear Formula: C₂₀H₁₇NO₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-14340-25MG	25 mg	$65.80 1/EA		Add To Favorites
45-14340-100MG	100 mg	$101.00 1/EA		Add To Favorites
45-14340-500MG	500 mg	$404.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.0% (TLC)
form	powder
InChI	1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChI key	IYGYMKDQCDOMRE-ZWKOTPCHSA-N
mp	193-197 °C
optical activity	[α]20/D +126±6°, c = 1% in chloroform
Quality Level	100
SMILES string	[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]4([H])N(C)CCc5cc6OCOc6cc45

Application:	Bicuculline has been used: • as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiol • to study the effects of chronic caffeine administration on the function of GABA_A receptor • to isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats
Biochem/physiol Actions:	(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.
Biochem/physiol Actions:	(+)-Bicuculline is a GABA_A receptor antagonist.
Features and Benefits:	This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description:	Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.

Symbol	GHS06,GHS09
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H400
Precautionary statements	P262 - P273 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
Hazard Codes	T,N
Risk Statements	23/24/25-50
Safety Statements	36/37-45-61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (TLC)
mp	193-197 °C
UNSPSC	12352200

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.