Biotin
SIAL/14400 - ≥99.0% (T)
Synonym: D-Biotin; Bios II; Coenzyme R; Vitamin B7; Vitamin H
CAS Number: 58-85-5
Empirical Formula (Hill Notation): C10H16N2O3S
Molecular Weight: 244.31
EC Number: 200-399-3
MDL Number: MFCD00005541
Linear Formula: C10H16N2O3S
Product Type: Chemical
| application(s) | detection |
| assay | ≥99.0% (T) |
| biological source | synthetic |
| cation traces | Ca: ≤50 mg/kg |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤10 mg/kg | |
| K: ≤50 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Na: ≤500 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | colorless to white |
| form | powder |
| ign. residue | ≤0.1% (as SO4) |
| InChI | 1S/C10H16N2O3S/c13-8(14)4 |
| InChI key | YBJHBAHKTGYVGT-ZKWXMUAHSA |
| loss | ≤0.5% loss on drying |
| mp | 229-234 °C |
| 231-233 °C (lit.) | |
| optical activity | [α]20/D +91±2°, c = 1% in 0.1 M NaOH |
| Quality Level | 200  |
| SMILES string | [H][C@]12CS[C@@H](CCCCC(O |
| solubility | 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless |
| alcohol: soluble 80mg/100 ml at 25 °C | |
| H2O: very soluble | |
| organic solvents: insoluble | |
| water: soluble 22mg/100 ml at 25 °C |
| Application: | Biotin has been used for testing the functionality of the Avidin-displaying phages. The product has also been used for labeling the swine anti-rabbit IgG antibody and peroxidase. |
| Biochem/physiol Actions: | Biotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. Biotin favors keratin synthesis and hence is used as a supplement for hair and nail growth. Deficiency of biotin shows several symptoms such as alopecia, conjunctivitis, seborrheic dermatitis, depression, lethargy, hypotonia and seizures. |
| Biochem/physiol Actions: | Biotin also referred to as vitamin H or vitamin B7 is a water-soluble B-vitamin that induces two to three fold increase in guanylate cyclase activity in rat liver, kidney, colon, cerebellum, and heart. It also stimulates the sperm motility and prolongs the survival of cryopreserved human spermatozoa. |
| General description: | Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin. |
| Other Notes: | Reviews; Avidin-Biotin technology; |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (T) |
| mp | 229-234 °C; 231-233 °C (lit.) |
| UNSPSC | 12352201 |