N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane

SIAL/15209 - for GC derivatization, LiChropur^™, contains 10% TMCS, 98% (excluding TMCS)

Synonym: BSTFA + TMCS

CAS Number: 25561-30-2
Empirical Formula (Hill Notation): C₈H₁₈F₃NOSi₂
Molecular Weight: 257.40
MDL Number: MFCD00008269
Linear Formula: CF₃C[=NSi(CH₃)₃]OSi(CH₃)₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-15209-10X1ML	1 mL	$263.00 10/EA		Add To Favorites
45-15209-5ML	5 mL	$56.70 1/EA		Add To Favorites
45-15209-25ML	25 mL	$274.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97.5% (excluding TMCS, GC)
	98% (excluding TMCS)
bp	45-50 °C/14 mmHg (lit.)
density	0.97 g/mL (lit.)
form	liquid
grade	for GC derivatization
impurities	9.0-11.0% TMCS
InChI	1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
InChI key	XCOBLONWWXQEBS-KPKJPENVSA-N
quality	LiChropur^™
Quality Level	100
reaction suitability	reagent type: derivatization reagent reaction type: Silylations
refractive index	n20/D 1.384 (lit.)
SMILES string	C[Si](C)(C)OC(=N[Si](C)(C)C)C(F)(F)F
technique(s)	gas chromatography (GC): suitable

Application:	Determination of Δ(9)-tetrahydrocannabinol, 11-nor-carboxy-Δ(9)-tetrahydrocannabinol and cannabidiol in human plasma and urine after a commercial cannabidiol oil product intake.: This study uses N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for derivatization to enhance the sensitivity and accuracy of cannabinoid detection in biological samples. This method is vital for forensic toxicology and clinical research, providing reliable data for cannabinoid analysis (Papoutsis et al., 2024 ). The impact of lipid degradation on fingerprint quality on fired firearm cartridges.: This research employs N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane to study lipid degradation and its effect on fingerprint quality on firearm cartridges. The findings are crucial for forensic science, particularly in improving methods for preserving and analyzing fingerprint evidence (Goulart et al., 2023 ). Contaminants of emerging concern: Silylation procedures, evaluation of the stability of silyl derivatives and associated measurement uncertainty.: This paper evaluates the use of N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane in silylation procedures for environmental analysis. The study assesses the stability and measurement uncertainty of silyl derivatives, which is crucial for accurate monitoring of environmental contaminants (Ljoncheva et al., 2023 ). Screening of Organic Acidurias by Gas Chromatography-Mass Spectrometry (GC-MS).: This research utilizes N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane in the derivatization process for screening organic acidurias. This method is significant for clinical diagnostics, providing a reliable approach for detecting metabolic disorders (Scott et al., 2022 ). A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction-gas chromatography-mass spectrometry.: The study presents a method using N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for the detection of hormones in environmental samples. This robust method is essential for monitoring water quality and detecting endocrine-disrupting compounds (Chafi and Ballesteros, 2022 ).
General description:	N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane has found application to be used in gas chromatography (GC) and mass-spectrometry (MS). It can also be used in HPLC- electrochemical detection assay of 8-oxo-deoxyguanosine and?8-oxo-guanine.
Legal Information:	LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Other Notes:	The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.
Packaging:	10×1 mL in ampule
Packaging:	5 mL in glass bottle

Symbol	GHS02,GHS05,GHS07
Signal word	Danger
Hazard statements	H225 - H302 - H314
Precautionary statements	P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Codes	F,C
Risk Statements	11-14-35
Safety Statements	16-26-36/37/39-45
RIDADR	UN 2924 8(3) / PGII
WGK Germany	WGK 3
Flash Point(F)	15.8 °F - closed cup
Flash Point(C)	-9 °C - closed cup

Purity	≥97.5% (excluding TMCS, GC); 98% (excluding TMCS)
bp	45-50 °C/14 mmHg (lit.)
Density	0.97 g/mL (lit.)
Refractive Index	n20/D 1.384 (lit.)
UNSPSC	41116105

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