Monoethylglycinexylidine

SIAL/16866 - analytical standard

Synonym: MEGX; MGEX; Monoethylglycinexylidide; N-(2,6-dimethylphenyl)-2-(ethylamino)acetamide; Norlidocaine

CAS Number: 7728-40-7
Empirical Formula (Hill Notation): C₁₂H₁₈N₂O
Molecular Weight: 206.28
MDL Number: MFCD00098991
Linear Formula: C₁₂H₁₈N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-16866-25MG	25 mg	$207.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

application(s)	pharmaceutical
assay	≥98.0% (HPLC)
format	neat
grade	analytical standard
InChI	1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
InChI key	WRMRXPASUROZGT-UHFFFAOYSA-N
Quality Level	100
shelf life	limited shelf life, expiry date on the label
SMILES string	CC1=C(NC(CNCC)=O)C(C)=CC=C1
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Application:

Pharmacokinetic Analysis: A study by Liu ZY et al. examines the pharmacokinetics of intravenous and topical lidocaine in patients undergoing thoracoscopic pulmonary resection. This research, which could integrate compounds like Monoethylglycinexylidine for analytical validation, highlights the importance of understanding drug dynamics for improving surgical outcomes (Liu et al., 2024 ).

Veterinary Pharmacology: Knych HK et al. explore the pharmacokinetics and metabolism of lidocaine in horses following a palmar digital nerve block. Studies like this could benefit from the use of Monoethylglycinexylidine as a standard for accurate drug measurement and monitoring in veterinary medicine, ensuring safe and effective dosing (Knych et al., 2023 ).

Anesthesia Research: Crouch CE et al. provide insights into the pharmacokinetics of lidocaine intraoperative infusion during partial hepatectomy for living liver donation. Research utilizing Monoethylglycinexylidine could enhance the understanding of local anesthetics′ systemic effects, contributing to safer anesthetic practices (Crouch et al., 2023 ).

Anesthetic Efficacy in Avian Species: Escobar A et al. investigate the effects of two continuous infusion doses of lidocaine on isoflurane minimum anesthetic concentration in chickens. Incorporating Monoethylglycinexylidine in such studies could refine our understanding of dose-dependent effects and optimize anesthetic protocols for non-mammalian species (Escobar et al., 2023 ).

Clinical Pharmacokinetics: Jin Y et al. discuss the simultaneous determination of lidocaine and its active metabolites in plasma by UPLC-MS/MS, applied to a clinical pharmacokinetic study in liver cancer patients. Monoethylglycinexylidine could be used to validate and calibrate assays, enhancing the reliability of pharmacokinetic data in clinical settings (Jin et al., 2022 ).

Biochem/physiol Actions:

Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine.

Symbol	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301 + P310
Hazard Codes	Xn
Risk Statements	22
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.0% (HPLC)
UNSPSC	41116107

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