Heparin sodium salt from porcine intestinal mucosa
SIAL/2106 - endotoxin, free
CAS Number: 9041-08-1
MDL Number: MFCD00081689
Product Type: Chemical
| biological source | Porcine intestinal mucosa |
| compatibility | for use with E-Toxate™ |
| form | powder |
| impurities | endotoxin, free |
| packaging | preweighed vial of 300 USP units |
| Quality Level | 200  |
| solubility | acetone: insoluble |
| alcohol: insoluble | |
| benzene: insoluble | |
| chloroform: insoluble | |
| diethyl ether: insoluble | |
| water: soluble 50 g/L | |
| usage | sufficient for 5 mL blood anticoagulant |
| Application: | Heparin sodium salt from porcine intestinal mucosa has been used as a M199 medium supplement used for maintaining human umbilical vein endothelial cells. |
| Biochem/physiol Actions: | Heparin sodium salt is the salt form of heparinic acid and is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. It is an anticoagulant that produces its major anticoagulant effect by activating antithrombin. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor and accelerates significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (factor Xa and thrombin). Additionally, it also facilitates the stabilization and regulation of tryptase as an enzymatically active tetramer. |
| Caution: | Not for injection. |
| Legal Information: | E-Toxate is a trademark of Sigma-Aldrich Co. LLC |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12352201 |