Calcium ionophore III

SIAL/21186 - Selectophore^™, function tested

Synonym: Calcium Ionophore A23187; Antibiotic A 23187; Calimycin

CAS Number: 52665-69-7
Empirical Formula (Hill Notation): C₂₉H₃₇N₃O₆
Molecular Weight: 523.62
EC Number: 258-084-1
MDL Number: MFCD00151202
Linear Formula: C₂₉H₃₇N₃O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-21186-5MG-F	5 mg	$129.00 1/EA	Add To Favorites
45-21186-25MG-F	25 mg	$466.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 21186-5MG-F

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-positive bacteria
form	solid
grade	for ion-selective electrodes
InChI	1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChI key	HIYAVKIYRIFSCZ-CYEMHPAKSA-N
mode of action	cell membrane \| interferes
product line	Selectophore^™
quality	function tested
Quality Level	200
SMILES string	[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
storage temp.	2-8°C

Application:	CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca²⁺ dependent K⁺ channels as the K⁺ efflux.
Application:	Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.
Application:	Ionophore highly selective for Ca²⁺. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
General description:	Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca²⁺ ions across membranes along a concentration gradient.
General description:	Visit our Sensor Applications portal to learn more.
Legal Information:	Selectophore is a trademark of Sigma-Aldrich Chemie GmbH
Other Notes:	Preparation of an optical chemical sensor for Ca²⁺ and Mg²⁺
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	26111700

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